【 abstract 】objective Explore merger of depressive disorders patients with Parkinson disease (PD) health-related quality of life (QOL) HR -hods Will merge depression 76 cases of PD patients and 44 cases of PD patients without merge depression as the research object, the survey and compare the two sets of patients basic situation, depression (HRSD - 17 scale), health (SF - 36 scale) and life quality (PDQ - 39 scale)The results The PD patients merger depression HR - QOL is less than the PD patients merger depression (P < 001), and with the increase of the patients with depression degree hr-v QOL Quality of life of the patients of PD using Logistic regression analysis to influence factor analysis found that course, depression degree and daily levodopa dose is independent of the influence factors, including depression degree of the quality of life of the patients the maximum impact, OR = lusion Depression is the effect of PD patients HR - QOL most main Reduce PD patients to improve the symptoms of depression patients is important HR - QOL