With the development of productive forces, the world is speeding up the process of economic integration, globalization has become overwhelming For any enterprise, to seek greater development of the world will be an inevitable Transnational business enterprises operating environment is different from the local community, such changes not only from differences in language, the geographical differences, is more important to cultural differences, cross-cultural management to the success of the relationship between the success or failure of corporate globalization This paper introduced the first cross-cultural management and the significance of existing research position at home and abroad, and cross-cultural management, and other basic definition of a summary and analysis of the cultural differences in the multi-national corporations to operate in the decision-making, personnel and marketing, and so the role of And impact, concludes with a corresponding countermeasures, aimed at managers to find the angle of transnational business deal with cultural differences in the most reasonable