Negotiators from different cultures have different communication mode, values and thinking mode, this would mean that in international business negotiations to understand different cultures, and familiar with all business activities of the cultural differences is very International business communication research, thereby increasing international business negotiation has many positive This paper in the United States and Japan, for example, mainly discusses the cultural difference to negotiation, negotiation organizational, communication process, decision-making mode, agreement form and interpersonal relationships, etc, this paper analyzes the influence of American and Japanese negotiations with the coping technique and to promote the effective and efficient negotiations